Hair Exosomes
& PDRN Therapy
Exosomes and PDRN (Polydeoxyribonucleotide) represent the next generation of hair restoration moving beyond growth factors into cellular repair and regeneration.
Overview
Understanding Hair Exosomes & PDRN Therapy
Exosomes and PDRN (Polydeoxyribonucleotide) represent the next generation of hair restoration moving beyond growth factors into cellular repair and regeneration. Exosomes are nano-sized messengers naturally secreted by stem cells; they carry signals that instruct follicles to enter the growth phase, reduce inflammation, and improve scalp health at a cellular level. PDRN, derived from salmon DNA, works by activating adenosine receptors in the scalp stimulating tissue repair, improving blood supply, and creating the right environment for follicle recovery. Used together, they address hair loss from two complementary angles: regeneration and repair.
WHO IT SUITS
Is This Right for You?
Androgenetic alopecia (male or female pattern hair loss) – early to moderate stages
Diffuse thinning with poor hair quality and scalp inflammation,Those who have not responded adequately to PRP or want to upgrade their treatment.Alopecia areata as an adjunct to other therapies.Patients wanting a drug-free, biologically based approach.Post-partum or stress-related hair loss with delayed recovery
Like PRP, these treatments work best when follicles are still present. Early intervention yields better outcomes. Also combination with medical therapy is necessary
OUR APPROACH
How We Treat at ZARS
Exosomes and PDRN are administered via microinjections into the scalp in a systematic pattern targeting areas of active thinning. At Zars, the two are often used in combination PDRN lays the groundwork by repairing the scalp microenvironment, while exosomes deliver the regenerative signals directly to the follicles. The treatment can also be combined with microneedling or a dermaroller to enhance depth of penetration and distribution across the scalp.
Both are cell-free, biocompatible treatments no blood draw is required, which makes them particularly suitable for patients who are not candidates for PRP or prefer a simpler procedure.
A thorough scalp assessment is done at consultation including trichoscopy where indicated to map the pattern, density, and scalp condition before treatment begins.
WHAT TO EXPECT
Your Treatment Journey
BEFORE
Come with a clean scalp, free of oil or styling products. Stay hydrated and have a light meal. Avoid NSAIDs for 48 hours prior. No special prep beyond this.
DURING
The solution is administered via fine microinjections across the scalp. Topical anaesthetic is applied beforehand. Sometimes local anesthesia is used in select cases. The sensation is mild; most patients find it comparable to or more comfortable than PRP. The session takes 30-45 minutes.
AFTER
Mild redness or a sensation of tightness on the scalp for 24–48 hours is normal. Avoid washing the hair for 24 hours, and skip heat styling, heavy exercise, and direct sun on the day of treatment. Normal hair care resumes the next day. No downtime.
RESULTS
What You Can Achieve
Reduced shedding and improved scalp condition are typically the earliest changes, noticed within 4–6 weeks. Improvement in hair density and thickness follows over 3-6 months, with results continuing to develop for up to a year. Because exosomes and PDRN work at a cellular level, the response tends to be progressive. Patience and consistency with the full course are important.
Results are enhanced significantly when combined with medical therapy (minoxidil, supplements) and maintained with periodic top-up sessions.
FAQS
Common Questions
How is this different from PRP?
PRP uses concentrated growth factors from your own blood. Exosomes and PDRN are cell-free, off-the-shelf biologics that work at a deeper cellular level. Exosomes carry a broader range of regenerative signals than PRP, and PDRN focuses specifically on tissue repair and improving scalp vascularity. They are often considered a step up from PRP, or used when PRP has not delivered sufficient results.
How many sessions are needed?
Discomfort is minimal. Topical anaesthetic is applied before the session, and most patients find it more comfortable than PRP. Mild scalp sensitivity for 24-48 hours post-treatment is normal and settles on its own.
How many sessions are needed?
An initial course of 3-4 sessions spaced 3-4 weeks apart, followed by maintenance every 4-6 months. As with all hair loss treatments, maintenance is essential. Hair loss is a continuing process and periodic sessions sustain what the initial course achieves.
Can it be combined with other hair loss treatments?
Yes and combination therapy is usually recommended. Exosomes and PDRN work well alongside minoxidil, nutritional supplementation, and in-clinic treatments like PRP or microneedling. Your doctor at Zars will personalise the plan based on your hair loss pattern, severity, and previous treatment history.
Explore Your Options
If you’d like to understand whether this treatment may be right for you, we’re here to help – without pressure or obligation.